Journal: Frontiers in Neurology
Article Title: Therapeutic Plasticity of Neural Stem Cells
doi: 10.3389/fneur.2020.00148
Figure Lengend Snippet: Human adult SGZ structure. Based on the report by Boldrini et al. neurogenesis persists during adulthood. The generation of new neurons starts from quiescent radial glia-like progenitor cells (type I). Type I cells become activated and then, by asymmetric division, generate intermediate progenitors (type II). Type II become neuroblasts or intermediate neural progenitors (INP type III) that convert into immature granule cells and finally mature into long-lasting granule cells that send their apical processes to the CA3 part of the hippocampus. On the other hand, according to Sorrells et al. neurogenesis is not detected in adult. In the dentate gyrus, a proliferative subgranular zone (SGZ) is not formed near the granular cell layer, and proliferative progenitor stem cells are scattered in the hilus only. They disappear anyway after 7 years from birth, and young neurons are not found in adult individuals. Curly brackets define the condition described in Sorrells et al. ( , , , , , , , ).
Article Snippet: Spinal Cord Injury , Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI (SCI) , Phase 1 , 8 , 18–65 , 54 , Human neural stem cell, spinal cord derived , N/A , Neuralstem Inc. , NCT01772810 , Recruiting.
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